Genetics

Chromosomal health is a crucial prerequisite for a healthy child. A healthy cell consists of 46 chromosomes, which contain the complete genetic information. In rare cases, disorders in the genetic make-up can occur.

  • Risk of micro-deletions („missing pieces“) of the Y-Chromosome due to poor sperm quality  
  • Obstruction of the seminal duct through a mutation in the CFTR gene (gene for the existence of cystic fibrosis)
  • Father and/or mother are carriers of changes in genetic material
  • Chromosomal maldistribution in oocytes
  • Maternal translocation (shift of a chromosome)

Karyogram: A simple translocation or the number of chromosomes can be determined with a blood test.

Polar body diagnostics: Examination of the polar body which develops during the meiosis of the oocyte. With polar body diagnostics we can only determine the genetic health of the oocyte and therefore only analyse the maternal part of the embryo.

Recommended in cases of: 

  • reduced ovarian reserve
  • increased ovarian reserve
  • higher maternal age (>37 years) 
  • known maternal genetic disorders
  • previous pregnancies with chromosome disorder of the child
  • carriers of severe hereditary diseases


Trophectoderm biopsy: Examination of the embryonic cells, which develop into the placenta. The trophectoderm biopsy offers the possibility to detect changes in paternal genetic material. This type of biopsy is used when the less invasive polar body diagnostics is insufficient.

Prerequisites: 

  • three or more IVF attempts without nidation with suspected chromosomal disorder of the embryos
  • three or more spontaneous miscarriages with suspected chromosomal disorder of the child
  • know maternal genetic disorder
  • previous pregnancies with chromosome disorder of the child
  • parent is carrier of a severe hereditary disease