A severe complication of hormonal stimulation of the ovaries is the hyper stimulation syndrome or OHSS. Symptoms include a considerable increase in the volume of the ovaries and sometimes even water collects around the ovaries. Luckily this severe form of OHSS does only occur in 0,1 – 2% of all patients. A promising treatment option based on newest study insights (published in the journal “Fertility & Sterility) shows:
The risk of OHSS can be significantly decreased by the use of calcium infusions. Without this treatment 8% of patients suffered from a medium symptomatic. In 4% the symptoms were severe. The calcium infusions proved to be successful – after the treatment only 1% of patients suffered from a medium OHSS and not a single one showed symptoms of the severe OHSS.
It is presumed that calcium lowers an important signal molecule (VEGF) which influences vessel diameters and vessel permiability. This is how calcium can prevent the development of OHSS or at least significantly lowers the possibility of OHSS. The calcium infusion shows only few side effects, still if can’t be used in patients suffering from heart diseases or cardiac arrhythmia.
If a patient suffers from OHSS the calcium infusion will be conducted for a time period of 30 minutes after the ovum pick-up and embryo transfer. More information can be requested from our office or nursing team!