In some cases even with a very satisfactory progression of the treatment and excellent embryo quality, pregnancy cannot be achieved. This recurring nidation failure (called “repeated implantation failure” – RIF) poses a large problem and it is presumed that in 66 % of such cases the endometrium does not accept the embryo. It is one of our main aims to solve this problem.
A current study reports an increase in pregnancy rates through the use of hCG-flushing (human chorionic gonadotropin) just after the ovum pick-up.
Effects of hCG-flushing
- the immunological tolerance of the uterus is positively influenced regarding the implementation
- the blood circulation of the uterus is increased
- the surface cells have more ability to retain the embryo
- the uterus muscles are less likely to convulse (this minimizes the risk of the embryo being repelled)
- an increase in progesterone receptors in the endometrium is achieved, this hormone is crucial in the implantation process
All these changes facilitate the implantation of the embryo and promote the transition from a non-responsive to a responsive uterus.
How does the hCG flushing work?
In the course of an IVF treatment, directly after the ovum pick-up the uterus is flushed with 500 units of hCG. This flushing procedure is integrated into the ovum pick-up procedure and so does not involve further time or effort for the patient. Up until now no complications regarding the hCG flushing have been observed and we expect good results by the use of this method.