Several studies are currently trying to answer the question whether there is a connection between elevated progesterone levels during the stimulation and the success rate of a treatment.
The stimulation of the ovaries with hormones is a crucial part of the IVF treatment. The formation of several follicles allows for the extraction of more oocytes and this in turn is a prerequisite for a greater chance at a successful outcome. “Naturally, the formation of these follicles changes hormone concentrations, above all the levels of oestrogen and progesterone as these are the most important hormones in the female monthly cycle” explains our medical director Prof.Dr. Andreas Obruca.
Over the past couple of months several studies have been trying to evaluate whether there is a connection between progesterone levels during the stimulation and the success rate of a treatment. The evidence seems to indicate that an elevated progesterone level on the day of the trigger injection – which takes place 2 days before the ovum pick-up – could have negative consequences for success. This progesterone elevation is evidently detrimental for nidation.
Prof. Dr. Obruca sees a possible solution: „It would be conceivable to cryopreserve all embryos of affected patients in order to transfer them in a later cycle when nidation conditions are ideal.” For the Kinderwunschzentrum it is now important to figure out whether such a progesterone elevation can be determined in our patients. Should the connection regarding the poor prognosis prove true, then the next step would be the consequent cryopreservation of all suitable embryos.